Manifold, a Newton, Massachusetts–based AI platform for the life sciences, has raised $18 million in Series B funding. 

Investors

The round was led by Reach Capital, with participation from SilverArc Capital, Industry Ventures, and existing investors TQ Ventures and Calibrate Ventures. 

Reach Capital is a San Francisco–based venture capital firm focused on education technology, workforce development, and digital health. Spun off from the NewSchools Venture Fund in 2015, the firm primarily invests at the pre-seed, seed, and Series A stages. 

Manifold Use of Funds

The company will use the funding to expand its Agent OS, deepen collaboration and governance infrastructure, and scale its life sciences data ecosystem across discovery, development, and clinical care. 

About Manifold

Manifold is an AI platform purpose-built for the life sciences industry, enabling next-generation AI workflows from early discovery through precision medicine in the clinic. Designed to address the complexity of biomedical data and multi-entity collaboration, Manifold supports agentic AI operating on multimodal datasets across research, clinical development, and real-world evidence generation. Headquartered in Newton, Massachusetts, Manifold is used by biopharma companies, academic medical centers, and research institutions, including Foundation Medicine and the University of Virginia. 

Funding Details 

Company: Manifold, Inc. 

Raised: $18.0M 

Round: Series B 

Funding Date: December 2025 

Lead Investor: Reach Capital 

Additional Investors: SilverArc Capital; Industry Ventures; TQ Ventures; Calibrate Ventures 

Company Website: https://www.manifold.ai/  

Software Category: Vertical AI / Life Sciences AI Platform 

Source: https://www.businesswire.com/news/home/20251218184357/en/