Ambience Healthcare, a San Francisco, CA-based ambient AI platform for documentation, coding, and clinical documentation integrity (CDI), has raised $243 million in a Series C funding round.
Investors
The round was co-led by Oak HC/FT and Andreessen Horowitz (a16z), with participation from OpenAI Startup Fund, Kleiner Perkins, Optum Ventures, Frist Cressey Ventures, Town Hall Ventures, Smash Capital, Georgian, and Founders Circle Capital.
Oak HC/FT is a venture and growth equity firm specializing in fintech and healthcare investments. Built on a foundation of partnership, Oak HC/FT supports companies and founders at every stage—from seed to growth—to build businesses that make a measurable and lasting impact. Founded in 2014, Oak HC/FT has invested in over 105 portfolio companies and manages more than $5.3 billion in assets. The firm is headquartered in Stamford, CT, with an office in San Francisco, CA.
Andreessen Horowitz is a Silicon Valley-based venture capital firm that invests in software, fintech, bio/health, crypto, gaming, and artificial intelligence. As of 2025, Andreessen Horowitz (a16z) manages approximately $45 billion in assets under management (AUM).
Ambience Healthcare Use of Funds
The company will use the funding to expand its AI platform across more healthcare organizations, accelerate product development, and support broader deployment across ambulatory, emergency, and inpatient care settings.
About Ambience Healthcare
Founded in 2020 by Mike Ng and Nikhil Buduma, Ambience Healthcare is an AI platform for documentation, coding, and clinical workflow, built to reduce administrative burden and protect revenue integrity at the point of care. Its platform is live in outpatient, emergency, and inpatient settings, supporting more than 100 specialties with real-time, coding-aware documentation. The platform integrates directly with Epic, Oracle Cerner, athenahealth, and other major EHRs. Headquartered in San Francisco, CA, Ambience is used by leading U.S. health systems including the Cleveland Clinic, UCSF Health, Houston Methodist, and Memorial Hermann.
Funding Details
Company: Ambience Healthcare, Inc.
Raised: $243.0M
Round: Series C
Funding Date: July 2025
Lead Investors: Oak HC/FT, Andreessen Horowitz (a16z)
Additional Investors: OpenAI Startup Fund, Kleiner Perkins, Optum Ventures, Frist Cressey Ventures, Town Hall Ventures, Smash Capital, Georgian, Founders Circle Capital
Company Website: https://www.ambiencehealthcare.com/
Software Category: Healthcare AI / Ambient AI / Clinical Documentation
Source: https://www.ambiencehealthcare.com/blog/ambience-healthcare-announces-243-million-series-c-to-scale-its-ai-platform-for-health-systems